Recently, a particular college football coach has justified his support for a rule that would allow substitution of defensive players within the first 10 sec of the play clock by claiming that this is a player safety issue. He has stated that he is concerned about his players that have sickle cell trait and how the exertion of playing defense may trigger sickling and death. Is this really a concern for defensive players during a game? It is true that sickle cell trait occurs in...