Reduced mechanical loading during bedrest, spaceflight, and casting, causes rapid morphological changes in skeletal muscle: fiber atrophy and reduction of slow-twitch fibers. An emerging signaling event in response to unloading is the translocation of neuronal nitric oxide synthase from the sarcolemma to the cytosol. Dr. John Lawler, Huffines Affiliate and Director of the Redox Biology and Cell Signaling Laboratory, recently published in the American Journal of Physiology: Regulatory, Integrativ...