Regular physical activity prevents cardiovascular disease, obesity, and type II diabetes. When objectively measured, ~3.5% of adults meet the recommended daily physical activity guidelines. Data have shown that physical activity levels are influenced by genetic mechanisms; however, the identity of the genetic mechanisms involved remains unclear despite efforts to determine genomic variance and transcripts associated with activity levels.Huffines Affiliate Dr. David Ferguson recently published an...

Vivo-morpholinos are a promising tool for gene silencing. These oligonucleotide analogs transiently silence genes by blocking either translation or pre-mRNA splicing. Little to no toxicity has been reported for vivo-morpholino treatment. Huffines Affiliate, Dr. David Ferguson, recently published in BioTechniques. His publication titled "Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity." explains studies conducted in their lab where treatment of mice wit...